Caffeine (1,3,7-Trimethylxanthine) as a modulator of Arsenic bioaccumulation in the experimental Pelecypod model, Lamellidens corrianus

Document Type : Original Article


Departments of Interpathy Research and Technology and Ayush, Maharashtra University of Health Sciences, Nashik, Maharashtra, India


Aims: The present investigation was carried out to study modulator effect of caffeine (1,3,7-Trimethylxanthine) on Arsenic-induced alterations on freshwater bivalve, Lamellidens corrianus. Materials and Methods: Freshwater Pelecypod Mollusc, L. corrianus were exposed to acute dose of arsenic (0.672 ppm As 3+ ) for 4 days. Arsenic exposed Bivalves were allowed to cure naturally and with caffeine. Testis and digestive glands from different groups were removed and dried in the oven. The dry powders were digested in nitric acid and perchloric acid in 4:1 ratio at hot temperature till dryness. The digest was dissolved in double glass distilled water and the arsenic contents were estimated by the Atomic Absorption Spectrophotometer. Results: After 4 days of exposure, the amount of bioaccumulated arsenic in the testis and digestive glands was 1.044 and 1.119 μg/g. During the recovery after 4 days, the bioaccumulated arsenic was reduced to 0.969 and 1.067 μg/g of normal water while in caffeine exposed Bivalves was reduced to 0.917 and 0.975 μg/g in testis and digestive glands respectively. Conclusion: Rapid reduction in the arsenic contents in caffeine exposed Bivalves indicates the role of caffeine in arsenic excretion. Therefore, the caffeine (1,3,7-Trimethylxanthine) as a modulator of Arsenic bioaccumulation in the experimental Pelecypod model, L. corrianus


Volume 3, May
May 2014
Pages 7-11
  • Receive Date: 02 February 2023
  • Accept Date: 02 February 2023