Aims: This study has been conducted to focus on the localization of the design parameters used for the design of wastewater treatment plants in a region of Iran. Materials and Methods: Three wastewater treatment plants were selected (as models) in a cold weather region of Iran. The main characteristics of the wastewater, such as, flow rate and its fluctuations, total solids, and the organic and nutrient contents, which play an important role in the design and operation of the wastewater treatment facilities, were measured for the selected plants during a year. Results: The averages of the design parameters for the investigated plants, including, biochemical oxygen demand (BOD 5 ), chemical oxygen demand (COD), total suspended solids (TSS), volatile suspended solids (VSS), total Kjeldahl nitrogen (TKN), and total phosphorous (TP) were, 41, 60, 65, 47, 8.3, and 0.93 g/capita, respectively. Wastewater production was 177 lit/cap-day with a maximum and minimum coefficient of 1.76 and 0.29, respectively. Conclusions: Using design parameters based on the local characteristics and the real-world conditions of the wastewater, can result in more+operational efficiency in the wastewater plants. It is suggested that the results of this study can be applied to the design of wastewater facilities throughout Iran, with the same local conditions.