Aims: The aim of this study was to investigate the relationship between macroergonomics score and job satisfaction among industrial employees. Materials and Methods: This cross-sectional study was done among 83 employees from a factory affiliated with Iran Khodro Company. Two questionnaires including Minnesota Job Satisfaction and Macroergonomics Condition have been used. Finally, the collected data was evaluated and analyzed through SPSS 10 software program. Results: The mean age of the subjects in this study was 30.8 and the work experience of 56.6% of them was between 4 and 7 years. The average macroergonomics score in the whole group in this study was 59.8. The maximum score given to this condition was 85, and the minimum score was 30. Also, the mean of job satisfaction score among the subjects was 60.5. The highest job satisfaction score was related to supervisors, which was about 69.2. There was a significant relationship between the general area of macroergonomics and job satisfaction. (r = 0.638, P-value <0.001). Conclusions: This study showed the higher macroergonomic scores, the better the work conditions, and, therefore, the employee's job satisfactions improve.