Aims: The main goal of this study was to present a reference model for the Health, Safety, Environment and Ergonomic HSEE performance measurement system. Materials And Methods: This study was done in a petrochemical unit in Iran during the year 2009. In first step, the existing information systems and their effect on personals were evaluated. Then the HSEE performance indicators were determined. The number of indicators were 244. After designing and implementing of the continuous monitoring system, the mentioned indicators were measured and controlled, continually. Results: In cases that the indicators showed deviation from defined criteria, corrective actions can be done with forecasting and introducing some suitable techniques for hazard identification and problem solving. With implementation of the integrated performance measuring system unsafe behavior, musculoskeletal disorder and suitability of HSEE committee discussions were improved 12%, 7.3% and 22.6%, respectively. Conclusion: The findings of this study emphasis on the need to conduct further research on the continuous monitoring of mentioned system in future years and performing necessary corrections. To improve the system performance, the continuous correction of indicators and related decision criteria, regular training of personal and implementation of award system are suggested.