Aims: The purpose of this study was to investigate adsorption isotherms of removing bisphenol A (BPA) from aqueous solutions using magnetic nanoparticles Fe3O4 and SiO2. BPA is an endocrine disrupting chemical that has caused great concern because of its potential risk to human health. Materials and Methods: The combined of magnetic nanoparticles Fe3O4 and SiO2 were applied to remove BPA from aqueous solution at a dose of 2 g/L. Isotherm Fitting Tool software was used for isotherm study in contact time 20 min, the initial concentration of BPA 0–10 (interval 1 mg/L), and pH 5. Results: The maximum adsorption efficiency was found to be 55%. The results of our experiments showed that maximum adsorption efficiency was achieved at t = 20 min and pH 5. Conclusion: The isotherm study showed that Langmuir isotherm described the equilibrium adsorption data better than other isotherms alternative.