Aim: Application of composting process for the management of organic solid waste led to the production of leachate, which causes many problems to environment. This study was aimed at investigation of ferro-sonication (FS) process in composting leachate degradation. Materials and Methods: Leachate samples were collected in composting factory located in Isfahan. In each run, 400 ml of leachate was sonicationed through an ultrasonic homogenizer in a cylindrical glass reactor. Ferrous sulfate was added to the reactor as accelerator agent. The effect of various parameters including pH, ferrous sulfate doses, sonication times, and ultrasonic intensity was studied in the removal of chemical oxygen demand (COD) and biological oxygen demand (BOD) from composting leachate. Results: The results showed that the COD and BOD removal rate was increased by increasing ferrous sulfate dosages, sonication time, and ultrasonic intensity. In addition, lower pH was favored for leachate degradation. In general, the optimum conditions for pH, ferrous sulfate dosage, irradiation time, and ultrasonic intensity were 3, 8 mmol, 180 min, and 150 W, respectively. Approximately 46% of COD and 33% of BOD were removed in optimum condition. Conclusion: These results revealed that FS can be effective in degradation of compost leachate and can be presented as a good choice for pretreatment of leachate.