Environmental health issues and epidemic pandemic aspects including infection spread during managing dead bodies revealed that infectious diseases and the associated mortality were often caused by infectious pathogens due to mismanagement of dead bodies. Dead body management is one of the main environmental health challenges during and after disasters and emergencies, especially following epidemic. This systematic review aimed to investigate the dead body management of epidemic victims. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In this study, electronic databases, including Web of Science, PubMed, Scopus, Pro Quest, Google Scholar, and Cochrane Library, were searched from March 1, 1970, to September 30, 2021. A comprehensive literature search was performed using scientific databases and gray literature. A thematic synthesis approach was used to analyze the data. In total, 2764 articles were identified, 11 of which met the inclusion criteria for entering the process of final synthesis. The findings showed three main sections, including (1) dead body management in the hospital and transfer of epidemic victims, (2) mortuary, shrouding, funeral, and burial of epidemic victims, and (3) management of families and risk communication. Implementation of the standards and protocols during dead body management of epidemic victims is essential with the aim of saving the lives of service providers and participants in ceremonial washing and burial.