Alkaline electrolyzed water (AEW) usually has a pH value ranging from of 8 to 10, and is postulated to produce many health benefits. Alkaline water consumption still invites a lot of controversy among health professionals and researchers. There were no comprehensive large-scale studies till date that compared the effects of AEW across various disease states targeting multiple system changes as outcomes. The present literature review was carried out to collate all the available clinical research works on Alkaline Water or AEW in improving disease state or promoting health. Search in various databases and search engines brought out 19 articles, of which nine met the eligibility criteria and were included for the analysis in the present study. The risk of bias and quality for every study included in the study were assessed. For all the randomized trials included in the study bias assessment was carried out using the Cochrane Risk-of-bias tool, and nonrandomized trials were assessed using nonrandomized studies of interventions tool. Reviewed studies have reported effects of AEW on oxidative stress, gastric cancer, blood sugar levels, exercise performance, blood viscosity, and gastrointestinal symptoms. AEW has shown considerable positive health effects in small-scale clinical studies. However, presently available evidence from the research works are not sufficient enough for recommendation to the mass in general or for use as a therapeutic intervention. Research works with larger study samples and among population of different demography are required.